From my personal experience, however, there is little chance of mania or anxiety even in high doses especially in comparison to DXM, and throughout the entire trip you will have a sense of contentment unwavering. I had structures I could interact with in the 3D world, put my arm behind and have my vision of my arm disappear but still being fully aware of the room I was in. The peak is reached about 2-3 hours after ingestion and will plateau for another 10 hours before slowly diminishing. Results: From 2010 to November 2019, 307 topics citing memantine were identified on reddit.com and 136 users experiences extracted from the topics were recorded. Sourcing drugs is NOT allowed here! Once this is tidied up a little i will make it a featured article on the mainpage and post it to our facebook group. In this study, we evaluated whether a combination of memantine with melatonin, administered for 32 days in drinking water, was more effective than either drug alone with respect to Aβ aggregates, neuroinflammation and cognition in the double transgenic APP/PS1 (5xFAD) mouse model of AD. The Memantine market has witnessed growth from USD XX million to USD XX million from 2014 to 2019. 30mg seems to be barely a threshold dose. Memantine helps to ease the symptoms of dementia in Alzheimer's disease. Although heavy doses are still somewhat forgiving, in my experience, I wouldn't start with anything higher than 100mg, even with dissociative tolerance, purely based on duration. The mean age of patients who were receiving memantine and placebo was about 34.7 ± 4.48 and 31.5 ± 7.4 years, respectively. Duration is manageable with correct dose amount and timing. Great write up, thanks for the info! I’d recommend slowly exploring higher doses, some of my heroic doses on Memantine have given me experiences I haven’t had on any other drug, and I’ve IM’d 300mg+ ketamine and taken doses as high as 125mg DCK, (on separate occasions) and they still haven’t touched the headspace I’ve reached on Memantine. Get your prescription refilled before you run out of medicine completely. Then memantine is pulled into the channel to its binding site. The half-life really makes this unsuited for recreational use imo. I light up a cigarette, like after most meals, and notice the slow whisps of smoke dancing around my hand, this is when I remembered about the Memantine, about 2 hours after taking the dose. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. I'm super happy I'm not the only one around here using it like this. If it isn't apparent guys, I have a lot of spare time. I have used ketamine in the past with the intention of helping depression and it was very pleasant at the time. Memantine HCl is an antagonist of NMDAR.It is also a CYP2B6 and CYP2D6 inhibitor for recombinant CYP2B6 and CYP2D6 with IC50 of 1.12 μM and 242.4 μM, Ki of … To me I'd describe it as similar physical euphoria to a high 2nd plateau/low 3rd plateau DXM, and similar emotional effects, but without the mindfuck that DXM can cause. Press J to jump to the feed. ... T+03:00 Texted my friend for a bit, browsed Reddit, watched YouTube. In addition, alcohol, opiates, stimulants and other dissociatives should be avoided when on recreational doses of Memantine as unwanted side effects, such as increased heart rates, respiratory depression, nausea and in worst case death, may occur. Both the research  and anecdotal reports  recount as much. I have just awoken at 90+ hours, and I think I'm finally pretty much back to baseline. Looks like you're using new Reddit on an old browser. I haven't pushed the limits enough to definitively say it exists. I may be an outlier with medical significance but if there's even one other person who finds it as beneficial as I do then I'm more than happy to share whatever information I can on Memantine. Whereas on DXM, it might be too hard to try to play a game. Memantine is an uncompetitive NMDA receptor antagonist, and subjectively feels somewhere between Ketamine & DXM (perhaps closer to one of PCP analogues, but I can't comment on their subjective effects) with a longer duration than either. Onset is between 45-180 minutes (As short as 30 minutes sublingually, from experience), so you'll be sitting around for a bit waiting for it to kick in. Memantine 20 mg compared to placebo for mild AD (MMSE 20‐23) observed case (OC) ‐ six‐month studies for dementia. Structures and voids are very apparent in low light and I would argue go beyond level 4. Memantine seems to work in 'waves' similar to that of LSD, although intervals are somewhat shorter between swells. Make sure you follow the RULES. Hey guys, some of you may recognise me as that guy who goes on and on about Memantine's recreational value whenever given the chance, but up until now I didn't really have a way to explain how one might approach Memantine if they were interested in it's recreational potential. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Memantine is great. Don't dismiss it based on the lack of information that exists on here and elsewhere currently on the internet. (Yes, citric acid causes your urine to become more alkaline, I learnt the hard way) A single oral dose is highly recommended. This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in … It's clean feeling, compared to DXM. Could you describe to me in as much detail as possible how it feels in comparison to traditional dissociatives such as ketamine, mxe and dxm? Pharms - Memantine (309), Sleep Deprivation (140) : General (1), First Times (2), Hangover / Days After (46), Multi-Day Experience (13), Various (28) COPYRIGHTS: All reports are copyright Erowid and you agree not to download or analyze the report data without … Common side effects … And anything else you might like to add. 3 McShane R, Westby MJ, Roberts E, Minakaran N, Schneider L, Farrimond LE, Maayan N, Ware J, Debarros J. Memantine as a treatment for dementia, Dementia and Cognitive Improvement Group. The best part of Memantine is that it's available on the clearnet, although you'll have to find sources yourselves. Low light settings let the visuals take hold much better and in complete darkness even 100mg may produce visuals on par with high Ketamine doses (for me high constitutes 200mg+), in a respective setting. Well dang, I'll have to figure out what my dose would be like (considering I have a dissociative tolerance currently). The visuals and euphoria become much more intense and interesting after weed is smoked. I was blown away the first time I tried Memantine with weed, it is comparable to DXM with and without weed. Memantine, 3-MEO-PCE, LSD, 4-AcO-MiPT, 4-HO-MET, 2C-C, Clonazepam & Aripiprazole: Adventures in NMDA Receptor Antagonism: viscosity: Memantine & DXM: Just the Kick in the Teeth I Was Looking For: 180OnTheDVP: Memantine & Nitrous Oxide: Beyond Tollerance Reduction: Clyde T. Its name is derived from its structure; 3,5-dimethyladamantan-1-amine. But if you like dissociatives like DXM/Ketamine, I think it's definitely worth trying. This is a risk reduction resource. Depth perception is by far the biggest impacted sense, and in low light settings will make the room you're in feel like its constantly moving between being a cathedral in size to a shoebox. Some gastro-intestinal disturbances could be possible however, due to D2 agonism, there's not much info on this. I've come to find that most chemicals go: I started taking memantine a few months ago, and have experimented a few times with higher recreational doses. How long do the effects last? Continuous outcomes. 85mg Memantine Trip Report from January 2019 (edited, repost) Experience Report. Don't re-dose thinking it wasn't a high enough dose, you'll regret the compounding effects of multiple doses. 278 Memantine blocks the extensive activity of NMDA receptors but does not accumulate to interfere with normal synaptic transmission, and hence no disruption of normal physiological activity. How often do you use Memantine for depression? Results were inconclusive because of studies with poor levels of … Memantine for dementia – what, why, who and when? Memantine is used for treatment of moderate-to-severe stage of AD. Due to its antagonism of the N-methyl-d-aspartate (NMDA) receptor, which has been shown to block rewarding and reinforcing effects of morphine, memantine has been investigated for potential utilization in … Sorry, this post was deleted by the person who originally posted it. Seeing as Erowid has limited information on Memantine this guide aims to add another resource out there. I smoke tobacco bongs regularly so I seek out heavy nicotine rushes, but when on Memantine most of the rush is gone and it turns into a more deliriant-like experience. One interesting memantine side effect includes higher libido. No sweating, over heating, or other common effects from stimulants, possibly due to how mild it's stimulant effects are (for me). The new dementia NICE guidelines published in June 2018 state that we should consider memantine for patients with moderate Alzheimer’s Disease and offer memantine for people with severe Alzheimer’s Disease, and if the person is already Take one dose every day, at the same time of day each day. Memantine was not effective at reducing cognitive deficits, and patients who tried memantine had more adverse effects such as fatigue . I feel very clear-headed on memantine. You can drink cranberry juice to acidify your urine throughout your trip to shorten it's duration, avoid citrus and other foods that basify your urine. Adding the Alzheimer drug memantine to a selective serotonin reuptake inhibitor (SSRI) may improve depressive symptoms, as well as apathy, anxiety, and cognitive function, in older patients. After I've eaten and sat down to begun browsing reddit, the fact I've taken the Memantine has almost completely been forgotten by me, I begin to feel a bit spacey and calm. With that being said, I don't think memantine would be an enjoyable experience for everyone. And personally I enjoy it a lot. Memantine is een geneesmiddel dat geregistreerd is voor de behandeling van patiënten met een matige tot ernstige vorm van de ziekte van Alzheimer.Het behandelt de oorzaak van de ziekte niet maar het laat toe dat patiënten misschien wat langer zelfstandig kunnen functioneren. Just remember that there is no 100% safe drug use. Memantine is a prescription drug that is also known by the brand name Namenda. I'm clumsy and stumbling a bit, but I'm able to use a keyboard and phone just fine. Deprescribing ChEIs and memantine through shared decision making with individuals and their caregivers by: determining their treatment goals; discussing benefits and harms of continuing and ceasing medication, from the start of therapy and throughout; and engaging them in monitoring after discontinuation, while informing carers that the individual will continue to decline after discontinuation. If you're aiming for a “K-hole” like experience, then I would not recommend Memantine, its difficult to achieve, if at all possible, and if it were, the duration of it would be far beyond reasonable. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. When in doubt, DON'T. Seems to help my short term memory. The one time I've combined LSD and a recreational dose of Memantine was one of the single most euphoric experiences I've ever had. Super Sour Ketamine is what I would describe the taste as. Thanks again dude. Do you have any previous experience with dissociatives, and if so how do they compare? Although I cannot back up this claim with empirical evidence, Memantine is potentiated by Cannabis. Reddit; Wechat; To the Editor, We read with interest the papers by Brenner 1 and Cimolai 2 regarding the therapeutic potential of memantine for coronavirus disease 2019 (COVID‐19). A recent meta-analysis found substantial benefits of memantine in treating obsessive-compulsive disorder. As many comparisons to other common compounds as possible would be extremely useful for fleshing out the subjective effects section. Visually fairly similar to ketamine, but more controllable. Population: mild Alzheimer's disease Intervention: memantine 20 mg Comparison: placebo . Psychonautwiki founder here, you did an amazing job on the mementine article dude. Euphoria is more and more present, but loss of fine and gross motor control becomes more apparent. Use memantine regularly to get the most benefit. And for the most part I'm perfectly functional cognivitely. The results have shown a significant difference in the behavior and attention deficit between the two groups treated with memantine and placebo during 6 weeks (p < 0.001). It has a pretty clear anxiolytic effect on me. For those who want to use memantine for treating … Memantine acts as a mild stimulant, raising heart rate and with a sense of weightlessness it feels encouraging to be physically active at low doses. It is a long acting NMDA receptor antagonist that binds to an open channel binding site. The biggest turn off I see people have with recreational use of Memantine is it's duration, and while not overly exaggerated it is manageable. 1. I don't think it's for everyone, but it certainly has enough merit for those who like dissociatives to try. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. 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